Recent publications

  1. Awwad O, Coperchini F, Pignatti P, Denegri M, Massara S, Croce L, Di Buduo CA, Abbonante V, Balduini A, Chiovato L, Rotondi M. The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration. J Endocrinol Invest. 2018 Mar 15.
  2. Balduini A, Raslova H, Di Buduo CA, Donada A, Ballmaier M, Germeshausen M, Balduini CL. Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26- and MYH9-related diseases. Eur J Med Genet. 2018 Mar 12.
  3. Avanzini MA, Abbonante V, Catarsi P, Dambruoso I, Mantelli M, Poletto V, Lenta E, Guglielmelli P, Croce S, Cobianchi L, Jemos B, Campanelli R, Bonetti E, Di Buduo CA, Salmoiraghi S, Villani L, Massa M, Boni M, Zappatore R, Iurlo A, Rambaldi A, Vannucchi AM, Bernasconi P, Balduini A, Barosi G, Rosti V; AGIMM Investigators. The spleen of patients with myelofibrosis harbors defective mesenchymal stromal cells. Am J Hematol. 2018 Jan 23.
  4. Malara A, Gruppi C, Celesti G, Abbonante V, Viarengo G, Laghi L, De Marco L, Muro AF, Balduini A. Alternatively spliced Fibronectin Extra Domain A is required for hemangiogenic recovery upon bone marrow chemotherapy. Haematologica. 2017 Nov 16.
  5. Zuccolo E, Di Buduo CA, Lodola F, Orecchioni S, Scarpellino G, Kheder DA, Poletto V, Guerra G, Bertolini F, Balduini A, Rosti V, Moccia F. Stromal cell-derived factor-1α promotes endothelial colony forming cell migration through the Ca2+-dependent activation of the extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/AKT pathways. Stem Cells Dev. 2017 Nov 9.
  6. Pouli D, Tozzi L, Alonzo CA, Liu Z, Kaplan DL, Balduini A, Georgakoudi I. Label free monitoring of megakaryocytic development and proplatelet formation in vitro. Biomed Opt Express. 2017 Sep 27;8(10):4742-4755.
  7. Grodzielski M, Di Buduo CA, Goette NP, Lev PR, Soprano PM, Heller PG, Balduini A, Marta RF. Autoantibodies in immune thrombocytopenia affect the physiological interaction between megakaryocytes and bone marrow extracellular matrix proteins. Br J Haematol. 2017 Oct 26.
  8. Di Buduo CA, Soprano PM, Tozzi L, Marconi S, Auricchio F, Kaplan DL, Balduini A. Modular flow chamber for engineering bone marrow architecture and function. Biomaterials. 2017 Nov;146:60-71.
  9. Erba BG, Gruppi C, Corada M, Pisati F, Rosti V, Bartalucci N, Villeval JL, Vannucchi AM, Barosi G, Balduini A, Dejana E. Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis. Am J Pathol. 2017 Aug;187(8):1879-1892.
  10. Di Buduo CA, Kaplan DL, Balduini A. In vitro generation of platelets: Where do we stand? Transfus Clin Biol. 2017 Sep;24(3):273-276.
  11. Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017 Aug 10;130(6):829-831.
  12. Abbonante V, Di Buduo CA, Gruppi C, De Maria C, Spedden E, De Acutis A, Staii C, Raspanti M, Vozzi G, Kaplan DL, Moccia F, Ravid K, Balduini A. A new path to platelet production through matrix sensing. Haematologica. 2017 Jul;102(7):1150-1160.
  13. Leiva O, Ng SK, Chitalia S, Balduini A, Matsuura S, Ravid K. The role of the extracellular matrix in primary myelofibrosis. Blood Cancer J. 2017 Feb 3;7(2):e525.
  14. Malara A, Fresia C, Di Buduo CA, Soprano PM, Moccia F, Balduini C, Zocchi E, De Flora A, Balduini A. The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes. J Biol Chem. 2017 Feb 24;292(8):3239-3251.
  15. Di Buduo CA, Balduini A, Moccia F. Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis. Int J Mol Sci. 2016 Dec 8;17(12).
  16. Melazzini F, Palombo F, Balduini A, De Rocco D, Marconi C, Noris P, Gnan C, Pippucci T, Bozzi V, Faleschini M, Barozzi S, Doubek M, Di Buduo CA, Kozubik KS, Radova L, Loffredo G, Pospisilova S, Alfano C, Seri M, Balduini CL, Pecci A, Savoia A. Clinical and pathogenic features of ETV6-related thrombocytopenia with predisposition to acute lymphoblastic leukemia. Haematologica. 2016 Nov;101(11):1333-1342.
  17. Björquist A, Di Buduo CA, Femia EA, Storey RF, Becker RC, Balduini A, Nylander S, Cattaneo M. Studies of the interaction of ticagrelor with the P2Y13 receptor and with P2Y13-dependent pro-platelet formation by human megakaryocytes. Thromb Haemost. 2016 Nov 30;116(6):1079-1088.
  18. Rotondi M, Coperchini F, Awwad O, Pignatti P, Di Buduo CA, Abbonante V, Magri F, Balduini A, Chiovato L. Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation. Mediators Inflamm. 2016;2016:8512417.
  19. Di Buduo CA, Currao M, Pecci A, Kaplan DL, Balduini CL, Balduini A. Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation. Haematologica. 2016 Dec;101(12):1479-1488.
  20. Di Sabatino A, Santilli F, Guerci M, Simeone P, Ardizzone S, Massari A, Giuffrida P, Tripaldi R, Malara A, Liani R, Gurini E, Aronico N, Balduini A, Corazza GR, Davì G. Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment. Thromb Haemost. 2016 Aug 30;116(3):486-95.
  21. Campanelli R, Fois G, Catarsi P, Poletto V, Villani L, Erba BG, Maddaluno L, Jemos B, Salmoiraghi S, Guglielmelli P, Abbonante V, Di Buduo CA, Balduini A, Iurlo A, Barosi G, Rosti V, Massa M; AGIMM Investigators. Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis. PLoS One. 2016 Jun 9;11(6):e0156990.
  22. Malara A, Gruppi C, Celesti G, Romano B, Laghi L, De Marco L, Muro AF, Balduini A. Brief Report: Alternative Splicing of Extra Domain A (EIIIA) of Fibronectin Plays a Tissue-Specific Role in Hematopoietic Homeostasis. Stem Cells. 2016 Aug;34(8):2263-8. 
  23. Di Buduo CA, Alberelli MA, Glembostky AC, Podda G, Lev PR, Cattaneo M, Landolfi R, Heller PG, Balduini A, De Candia E. Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients. Sci Rep. 2016 Mar 18;6:23213.
  24. Marconi C, Di Buduo CA, Barozzi S, Palombo F, Pardini S, Zaninetti C, Pippucci T, Noris P, Balduini A, Seri M, Pecci A. SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia.  Thromb Haemost. 2016 Jan 14;115(5). [Epub ahead of print]
  25. Abbonante V, Di Buduo CA, Gruppi C, Malara A, Gianelli U, Celesti G, Anselmo A, Laghi L, Vercellino M, Visai L, Iurlo A, Moratti R, Barosi G, Rosti V, Balduini A. Thrombopoietin/TGF-β1 loop regulates megakaryocyte extracellular matrix component synthesis. Stem Cells. 2016 Jan 9. [Epub ahead of print]
  26. An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, Farndale RW, Kaplan DL, Balduini A, Leitinger B, Brodsky B.  Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor. J Biol Chem. 2016 Feb 26;291(9):4343-55.
  27. Pietra D, Rumi E, Ferretti VV, Buduo CA, Milanesi C, Cavalloni C, Sant'Antonio E, Abbonante V, Moccia F, Casetti IC, Bellini M, Renna MC, Roncoroni E, Fugazza E, Astori C, Boveri E, Rosti V, Barosi G, Balduini A, Cazzola M. Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms. Leukemia. 2016 Feb;30(2):431-8.
  28. Coperchini F, Pignatti P, Carbone A, Bongianino R, Di Buduo CA, Leporati P, Croce L, Magri F, Balduini A, Chiovato L, Rotondi M. TNF-α increases the membrane expression of the chemokine receptor CCR6 in thyroid tumor cells, but not in normal thyrocytes: potential role in the metastatic spread of thyroid cancer. Tumour Biol. 2015 Nov 17. [Epub ahead of print]
  29. Balduini A, Di Buduo CA, Kaplan DL. Translational approaches to functional platelet production ex vivo. Thromb Haemost. 2016 Jan 27;115(2):250-6.
  30. Peloso A, Ferrario J, Maiga B, Benzoni I, Bianco C, Citro A, Currao M, Malara A, Gaspari A, Balduini A, Abelli M, Piemonti L, Dionigi P, Orlando G, Maestri M. Creation and implantation of acellular rat renal ECM-based scaffolds. Organogenesis. 2015;11(2):58-74.
  31. Brambilla M, Facchinetti L, Canzano P, Rossetti L, Ferri N, Balduini A, Abbonante V, Boselli D, De Marco L, Di Minno MN, Toschi V, Corsini A, Tremoli E, Camera M.  Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation. Thromb Haemost. 2015;114(3):579-92.
  32. Currao M, Malara A, Di Buduo CA, Abbonante V, Tozzi L, Balduini A.  Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions. Exp Cell Res. (2015); May 29. [Epub ahead of print]
  33. Abbonante V, Gruppi C, Catarsi P, Avanzini MA, Tira ME, Barosi G, Rosti V, Balduini A. Altered fibronectin expression and deposition by myeloproliferative neoplasm-derived mesenchymal stromal cells. Br J Haematol. 2016; 172(1):140-4.
  34. Di Buduo CA, Wray LS, Tozzi L, Malara A, Chen Y, Ghezzi CE, Smoot D, Sfara C, Antonelli A, Spedden E, Bruni G, Staii C, De Marco L, Magnani M, Kaplan DL, Balduini A. Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies. Blood (2015); Jan 9 [Epub ahead of print].
  35. Malara A, Abbonante V, Di Buduo CA, Tozzi L, Currao M, Balduini A. The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control. Cell Mol Life Sci. (2015); Jan 9. [Epub ahead of print]
  36. Bluteau D, Balduini A, Balayn N, Currao M, Nurden P, Deswarte C, Leverger G, Noris P, Perrotta S, Solary E, Vainchenker W, Debili N, Favier R, Raslova H. Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. J Clin Invest. (2014); 124(2):580-91.
  37. Di Buduo C, Moccia F, Battiston M, De Marco L, Mazzucato M, Moratti R, Tanzi F, Balduini A. The importance of calcium in the regulation of megakaryocyte function.  Haematologica (2014); 99(4):769-78.
  38. Achilli C, Jadhav SA, Guidetti GF, Ciana A, Abbonante V, Malara A, Fagnoni M, Torti M, Balduini A, Balduini C, Minetti G. Folic Acid-Conjugated 4-Amino-Phenylboronate, a Boron-Containing Compound Designed for Boron Neutron Capture Therapy, is an Unexpected Agonist for Human Neutrophils and Platelets. Chem Biol Drug Des (2014); 83(5):532-40.
  39. Pallotta I, Kluge JA, Moreau J, Calabrese R, Kaplan DL, Balduini A. Enhanced efficacy of platelet gels with silk. Biomaterials (2014); 35(11):3678-87.
  40. Malara A, Currao M, Gruppi C, Celesti G, Viarengo G, Buracchi C, Laghi L, Kaplan DL, Balduini A. Megakaryocytes Contribute to the Bone Marrow-MatrixEnvironment by Expressing Fibronectin, Type Iv Collagen and Laminin. Stem Cells. (2014); 32(4):926-37.
  41. An B, Abbonante V, Yigit S, Balduini A, Kaplan DL, Brodsky B. Definition of the Native and Denatured Type II Collagen Binding Site for Fibronectin Using a Recombinant Collagen System. J Biol Chem (2014); 289(8):4941-51.
  42. Achilli C, Grandi S, Ciana A, Guidetti GF, Malara A, Abbonante V, Cansolino L, Tomasi C, Balduini A, Fagnoni M, Merli D, Mustarelli P, Canobbio I, Balduini C, Minetti G. Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application. Nanomedicine. (2014); 10(3):589-97.
  43. Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A. Discoidin Domain Receptor 1 is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem. (2013) 288(23):16738-46.
  44. Currao M, Balduini CL, Balduini A. High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes. (2013) PLoS One. 8(1):e54723.
  45. Badalucco S, Di Buduo CA, Campanelli R, Pallotta I, Catarsi P, Rosti V, Kaplan DL, Barosi G, Massa M, Balduini A. Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis. (2013) Haematologica. 98(4):514-7.
  46. Balduini A, Di Buduo CA, Malara A, Lecchi A, Rebuzzini P, Currao M, Pallotta I, Jakubowski J, and Cattaneo M. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. (2012) Haematologica. 97(11):1657-65.
  47. Merico V, Zuccotti M, Carpi D, Baev D, Mulas F, Sacchi L, Bellazzi R, Pastorelli R, Redi CA, Moratti R, Garagna S, Balduini A. The genomic and proteomic blueprint of mouse megakaryocytes derived from embrionic stem cells. (2012) J. Thromb. Haemost. 10(5):907-15.
  48. Necchi V, Balduini A, Noris P, Barozzi S, Sommi P, Di Buduo CA, Balduini CL, Solcia E, Pecci A. Ubiquitin/proteasome-rich particulate cytoplasmic structures (PaCSs) in the platelets and megakaryocytes of ANKRD26-related thrombocytopenia. (2012) Thrombosis and Haemostasis; 109:263-271.
  49. Bury L, Malara A, Gresele P,  Balduini A. Outside-In signaling generated by constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocyte. (2012) PLoS ONE 7(4): e34449. doi:10.1371.
  50. Pallotta I, Lovett M, Kaplan DL, Balduini A. 3D system for the in vitro study of megakaryocytes and functional platelet production using silk-based vascular tubes. (2011) Tissue Eng Part C Methods 17:1223-32.
  51. Malara A, Gruppi C, Pallotta I, Spedden E, Tenni R, Raspanti M, Kaplan DL, Tira ME, Stai C, Balduini A. Extracellular matrix nano-mechanics determine megakaryocyte function. (2011) Blood 118(16):4449
  52. Malara A, Gruppi C, Rebuzzini P, Visai L, Perotti C, Moratti R, Balduini C, Tira ME, Balduini A. Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A. (2011) Blood 24;117(8):2476-83.
  53. Balduini A. New aspects of Filamin A versatility. (2011) Blood 118:2029-2030.
  54. Malara A, Balduini A. Blood Platelet Production and Morphology. (2011) Thrombosis Res. 129(3):241-44
  55. Balduini A, Malara A, Balduini CL, Noris P. Megakaryocytes derived from patients with the classical form of Bernard Soulier show no ability to extend proplatelets in vitro. (2011) Platelets 22:308-11.
  56. Vettore S, Tezza F, Malara A, Vianello F, Pecci A, Scandellari R, Floris M, Balduini A, Fabris F. A A386G biallelic GPIb{alpha} gene mutation with anomalous behavior: a new mechanism suggested for Bernard Soulier syndrome pathogenesis. (2011) Haematologica 96 (12):1878-82.
  57. Campanelli R, Rosti V, Villani L, Castagno M, Moretti E, Bonetti E, Bergamaschi G, Balduini A,  Barosi G, Massa M. Evaluation of the bioactive and total transforming growth factor β1 levels in primary myelofibrosis. (2011) Cytokine 53(1):100-6.
  58. Balduini A, Badalucco S, Pugliano MT, Baev D, Cattaneo M, Rosti V, Barosi G. In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes. (2011) PLoS ONE 6(6):e21015.
  59. Di Vito C, Bergante S, Balduini A, Rastoldo A, Bagarotti A, Surico N, Bertoni A, Sinigaglia F. The oestrogen receptor GPER is expressed in human haematopoietic stem cells but not in mature megakaryocytes. (2010) Br Journal Haematol 149(1):150-2.
  60. Pecci A, Malara A, Bauducco A, Bozzi V, Torti M, Balduini CL, Balduini A. Megakaryocytes of patients with myh9-related thrombocytopenia present an altered proplatelet formation. (2009) Thrombosis and Haemostasis, 102 (1): 90-6.
  61. Pallotta I, Lovett M, Rice W, Kaplan DL, Balduini A. Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis. (2009) PLoS ONE; 4: e8359.