Recent publications

  1. Di Buduo CA, Alberelli MA, Glembostky AC, Podda G, Lev PR, Cattaneo M, Landolfi R, Heller PG, Balduini A, De Candia E. Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients. Sci Rep. 2016 Mar 18;6:23213.
  2. Marconi C, Di Buduo CA, Barozzi S, Palombo F, Pardini S, Zaninetti C, Pippucci T, Noris P, Balduini A, Seri M, Pecci A. SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia.  Thromb Haemost. 2016 Jan 14;115(5). [Epub ahead of print]
  3. Abbonante V, Di Buduo CA, Gruppi C, Malara A, Gianelli U, Celesti G, Anselmo A, Laghi L, Vercellino M, Visai L, Iurlo A, Moratti R, Barosi G, Rosti V, Balduini A. Thrombopoietin/TGF-β1 loop regulates megakaryocyte extracellular matrix component synthesis. Stem Cells. 2016 Jan 9. [Epub ahead of print]
  4. An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, Farndale RW, Kaplan DL, Balduini A, Leitinger B, Brodsky B.  Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor. J Biol Chem. 2016 Feb 26;291(9):4343-55.
  5. Pietra D, Rumi E, Ferretti VV, Buduo CA, Milanesi C, Cavalloni C, Sant'Antonio E, Abbonante V, Moccia F, Casetti IC, Bellini M, Renna MC, Roncoroni E, Fugazza E, Astori C, Boveri E, Rosti V, Barosi G, Balduini A, Cazzola M. Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms. Leukemia. 2016 Feb;30(2):431-8.
  6. Coperchini F, Pignatti P, Carbone A, Bongianino R, Di Buduo CA, Leporati P, Croce L, Magri F, Balduini A, Chiovato L, Rotondi M. TNF-α increases the membrane expression of the chemokine receptor CCR6 in thyroid tumor cells, but not in normal thyrocytes: potential role in the metastatic spread of thyroid cancer. Tumour Biol. 2015 Nov 17. [Epub ahead of print]
  7. Balduini A, Di Buduo CA, Kaplan DL. Translational approaches to functional platelet production ex vivo. Thromb Haemost. 2016 Jan 27;115(2):250-6.
  8. Peloso A, Ferrario J, Maiga B, Benzoni I, Bianco C, Citro A, Currao M, Malara A, Gaspari A, Balduini A, Abelli M, Piemonti L, Dionigi P, Orlando G, Maestri M. Creation and implantation of acellular rat renal ECM-based scaffolds. Organogenesis. 2015;11(2):58-74.
  9. Brambilla M, Facchinetti L, Canzano P, Rossetti L, Ferri N, Balduini A, Abbonante V, Boselli D, De Marco L, Di Minno MN, Toschi V, Corsini A, Tremoli E, Camera M.  Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation. Thromb Haemost. 2015;114(3):579-92.
  10. Currao M, Malara A, Di Buduo CA, Abbonante V, Tozzi L, Balduini A.  Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions. Exp Cell Res. (2015); May 29. [Epub ahead of print]
  11. Abbonante V, Gruppi C, Catarsi P, Avanzini MA, Tira ME, Barosi G, Rosti V, Balduini A. Altered fibronectin expression and deposition by myeloproliferative neoplasm-derived mesenchymal stromal cells. Br J Haematol. 2016; 172(1):140-4.
  12. Di Buduo CA, Wray LS, Tozzi L, Malara A, Chen Y, Ghezzi CE, Smoot D, Sfara C, Antonelli A, Spedden E, Bruni G, Staii C, De Marco L, Magnani M, Kaplan DL, Balduini A. Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies. Blood (2015); Jan 9 [Epub ahead of print].
  13. Malara A, Abbonante V, Di Buduo CA, Tozzi L, Currao M, Balduini A. The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control. Cell Mol Life Sci. (2015); Jan 9. [Epub ahead of print]
  14. Bluteau D, Balduini A, Balayn N, Currao M, Nurden P, Deswarte C, Leverger G, Noris P, Perrotta S, Solary E, Vainchenker W, Debili N, Favier R, Raslova H. Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. J Clin Invest. (2014); 124(2):580-91.
  15. Di Buduo C, Moccia F, Battiston M, De Marco L, Mazzucato M, Moratti R, Tanzi F, Balduini A. The importance of calcium in the regulation of megakaryocyte function.  Haematologica (2014); 99(4):769-78.
  16. Achilli C, Jadhav SA, Guidetti GF, Ciana A, Abbonante V, Malara A, Fagnoni M, Torti M, Balduini A, Balduini C, Minetti G. Folic Acid-Conjugated 4-Amino-Phenylboronate, a Boron-Containing Compound Designed for Boron Neutron Capture Therapy, is an Unexpected Agonist for Human Neutrophils and Platelets. Chem Biol Drug Des (2014); 83(5):532-40.
  17. Pallotta I, Kluge JA, Moreau J, Calabrese R, Kaplan DL, Balduini A. Enhanced efficacy of platelet gels with silk. Biomaterials (2014); 35(11):3678-87.
  18. Malara A, Currao M, Gruppi C, Celesti G, Viarengo G, Buracchi C, Laghi L, Kaplan DL, Balduini A. Megakaryocytes Contribute to the Bone Marrow-MatrixEnvironment by Expressing Fibronectin, Type Iv Collagen and Laminin. Stem Cells. (2014); 32(4):926-37.
  19. An B, Abbonante V, Yigit S, Balduini A, Kaplan DL, Brodsky B. Definition of the Native and Denatured Type II Collagen Binding Site for Fibronectin Using a Recombinant Collagen System. J Biol Chem (2014); 289(8):4941-51.
  20. Achilli C, Grandi S, Ciana A, Guidetti GF, Malara A, Abbonante V, Cansolino L, Tomasi C, Balduini A, Fagnoni M, Merli D, Mustarelli P, Canobbio I, Balduini C, Minetti G. Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application. Nanomedicine. (2014); 10(3):589-97.
  21. Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A. Discoidin Domain Receptor 1 is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem. (2013) 288(23):16738-46.
  22. Currao M, Balduini CL, Balduini A. High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes. (2013) PLoS One. 8(1):e54723.
  23. Badalucco S, Di Buduo CA, Campanelli R, Pallotta I, Catarsi P, Rosti V, Kaplan DL, Barosi G, Massa M, Balduini A. Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis. (2013) Haematologica. 98(4):514-7.
  24. Balduini A, Di Buduo CA, Malara A, Lecchi A, Rebuzzini P, Currao M, Pallotta I, Jakubowski J, and Cattaneo M. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. (2012) Haematologica. 97(11):1657-65.
  25. Merico V, Zuccotti M, Carpi D, Baev D, Mulas F, Sacchi L, Bellazzi R, Pastorelli R, Redi CA, Moratti R, Garagna S, Balduini A. The genomic and proteomic blueprint of mouse megakaryocytes derived from embrionic stem cells. (2012) J. Thromb. Haemost. 10(5):907-15.
  26. Necchi V, Balduini A, Noris P, Barozzi S, Sommi P, Di Buduo CA, Balduini CL, Solcia E, Pecci A. Ubiquitin/proteasome-rich particulate cytoplasmic structures (PaCSs) in the platelets and megakaryocytes of ANKRD26-related thrombocytopenia. (2012) Thrombosis and Haemostasis; 109:263-271.
  27. Bury L, Malara A, Gresele P,  Balduini A. Outside-In signaling generated by constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocyte. (2012) PLoS ONE 7(4): e34449. doi:10.1371.
  28. Pallotta I, Lovett M, Kaplan DL, Balduini A. 3D system for the in vitro study of megakaryocytes and functional platelet production using silk-based vascular tubes. (2011) Tissue Eng Part C Methods 17:1223-32.
  29. Malara A, Gruppi C, Pallotta I, Spedden E, Tenni R, Raspanti M, Kaplan DL, Tira ME, Stai C, Balduini A. Extracellular matrix nano-mechanics determine megakaryocyte function. (2011) Blood 118(16):4449
  30. Malara A, Gruppi C, Rebuzzini P, Visai L, Perotti C, Moratti R, Balduini C, Tira ME, Balduini A. Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A. (2011) Blood 24;117(8):2476-83.
  31. Balduini A. New aspects of Filamin A versatility. (2011) Blood 118:2029-2030.
  32. Malara A, Balduini A. Blood Platelet Production and Morphology. (2011) Thrombosis Res. 129(3):241-44
  33. Balduini A, Malara A, Balduini CL, Noris P. Megakaryocytes derived from patients with the classical form of Bernard Soulier show no ability to extend proplatelets in vitro. (2011) Platelets 22:308-11.
  34. Vettore S, Tezza F, Malara A, Vianello F, Pecci A, Scandellari R, Floris M, Balduini A, Fabris F. A A386G biallelic GPIb{alpha} gene mutation with anomalous behavior: a new mechanism suggested for Bernard Soulier syndrome pathogenesis. (2011) Haematologica 96 (12):1878-82.
  35. Campanelli R, Rosti V, Villani L, Castagno M, Moretti E, Bonetti E, Bergamaschi G, Balduini A,  Barosi G, Massa M. Evaluation of the bioactive and total transforming growth factor β1 levels in primary myelofibrosis. (2011) Cytokine 53(1):100-6.
  36. Balduini A, Badalucco S, Pugliano MT, Baev D, Cattaneo M, Rosti V, Barosi G. In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes. (2011) PLoS ONE 6(6):e21015.
  37. Di Vito C, Bergante S, Balduini A, Rastoldo A, Bagarotti A, Surico N, Bertoni A, Sinigaglia F. The oestrogen receptor GPER is expressed in human haematopoietic stem cells but not in mature megakaryocytes. (2010) Br Journal Haematol 149(1):150-2.
  38. Pecci A, Malara A, Bauducco A, Bozzi V, Torti M, Balduini CL, Balduini A. Megakaryocytes of patients with myh9-related thrombocytopenia present an altered proplatelet formation. (2009) Thrombosis and Haemostasis, 102 (1): 90-6.
  39. Pallotta I, Lovett M, Rice W, Kaplan DL, Balduini A. Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis. (2009) PLoS ONE; 4: e8359.