Megakaryocytes and Bone Marrow Environment

Platelets derived from megakaryocytes (Mks) in the bone marrow play a central role in many physiological functions. However, there are many platelet-related diseases for which there are no current treatments other than palliative therapies, resulting in serious complications and side effects. Unraveling mechanisms of functional platelet formation from megakaryocytes would provide new options for therapeutic interventions. In our laboratory we pursue the understanding of these mechanisms by connecting medicine with biology, biotechnology and bioengineering research approaches.